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Inhibition of both skin and lung tumorigenesis by Car-R mouse-derived cancer modifier loci

TitoloInhibition of both skin and lung tumorigenesis by Car-R mouse-derived cancer modifier loci
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2002
AutoriSaran, Anna, Zaffaroni D., Pazzaglia Simonetta, Peissel B., Galbiati F., Spinola M., Manenti G., Zanesi N., Rebessi S., Mancuso Mariateresa, Covelli V., and Dragani T.A.
RivistaInternational Journal of Cancer
Volume97
Paginazione580-583
ISSN00207136
Parole chiaveAlleles, animal experiment, Animals, article, Breeding, cancer resistance, cancer risk, Carcinogenicity Tests, Carcinogens, Experimental, Female, gene locus, Genetic, Genetic Predisposition to Disease, Inbred Strains, Inbreeding, Incidence, lung cancer, lung carcinogenesis, Lung Neoplasms, male, Mice, mouse, Neoplasms, nonhuman, Outbred Strains, papilloma, Phenotype, Polymerase Chain Reaction, Polymorphism, priority journal, Proto-Oncogene Proteins, skin cancer, skin carcinogenesis, Skin Neoplasms, Tetradecanoylphorbol Acetate, Urethane
Abstract

The Car-R outbred mouse line was phenotypically selected for high resistance to two-stage skin tumorigenesis. In the present study we tested the hypothesis that a subset of genetic loci responsible for resistance to skin tumorigenesis of Car-R mice might also inhibit lung tumorigenesis. Skin and lung tumorigenesis were induced in groups of Car-R, SWR/J, (SWR/JxCar-R)FI and SWR/Jx(SWR/JxCar-R) backcross mice by i.p. urethane initiation and skin TPA promotion. Car-R mice showed a much lower susceptibility to both skin and lung tumorigenesis as compared to SWR/J mice, which are susceptible to both lung and skin tumorigenesis. The Car-R-inherited genome significantly inhibited both skin and lung cancer development in the FI progeny of Car-R with SWR/J mice. In the backcross population, skin and lung tumor phenotypes showed a statistically significant correlation, indicating that a subset of the cancer resistance alleles, which segregated in the Car-R line during selection for resistance to skin carcinogenesis, provides resistance to both skin and lung tumorigenesis. © 2002 Wiley-Liss, Inc.

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cited By 5

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0037050732&doi=10.1002%2fijc.10104&partnerID=40&md5=f1125e54843b28639b9cc7063277e875
DOI10.1002/ijc.10104
Citation KeySaran2002580