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Thermodynamic study of Langmuir antibody films for application to immunosensors

TitoloThermodynamic study of Langmuir antibody films for application to immunosensors
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione1991
AutoriAhluwalia, A., De Rossi D., Monici M., and Schirone Antonio
RivistaBiosensors and Bioelectronics
Volume6
Paginazione133-141
ISSN09565663
Parole chiaveAntibodies–Thermodynamics, Antibody, article, Biosensor, Biosensors–Design, Films–Langmuir-Blodgett, fluorescence, Immunoglobulin, immunoglobulin G, immunology, Immunosensors, Langmuir Antibody Films, priority journal, Thermodynamics–Calculations, Total Internal Reflection Fluorescence (TIRF)
Abstract

The thermodynamic functions, compressibility, entropy and free energy of desorption have been derived from a set of π-A isotherms of human immunoglobulin G films at an air-water interface. Criteria for optimum filmlift conditions have been obtained from an analysis of these functions. By the application of a basic model, a picture of the desorption behaviour of segments of the antibodies has also been constructed. The results of this study have been used to estimate the theoretical sensing limit of a TIRF based immunosensor. © 1991.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0025805893&doi=10.1016%2f0956-5663%2891%2987037-C&partnerID=40&md5=4aadc3fc85e09dc1c681f1b6fea0f628
DOI10.1016/0956-5663(91)87037-C
Citation KeyAhluwalia1991133