Titolo | High-intensity static magnetic field exposure devices for in vitro experiments on biopharmaceutical plant factories in aerospace environments |
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Tipo di pubblicazione | Presentazione a Congresso |
Anno di Pubblicazione | 2015 |
Autori | Lopresto, Vanni, Merla Caterina, Pinto Rosanna, and Benvenuto Eugenio |
Conference Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
Editore | Institute of Electrical and Electronics Engineers Inc. |
ISBN Number | 9781424492718 |
Abstract | Three high-intensity static magnetic field (SMF) exposure devices have been designed and realized for application to in vitro experimental research on hairy root cultures, supposed to grow in extreme environments- as those of space aircrafts- for producing biopharmaceutical molecules. The devices allow the exposure at two different levels of induction magnetic (B) field (250 mT and 500 mT) plus sham for blind exposure. The exposure levels can be considered representative of possible B-fields experienced within the habitat of a spacecraft in presence of active magnetic shielding systems. Each device can house a single 85-mm diameter Petri dish. Numerical simulations have been performed to accurately evaluate the B-field distribution in the biological target. Numerical results have been confirmed by measured data, proving that designed setups allows exposure to SMFs with a homogeneity better than 90%. The exposure devices will be employed for experiments scheduled within BIOxTREME research project, funded by the Italian Space Agency (ASI). © 2015 IEEE. |
URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953288992&doi=10.1109%2fEMBC.2015.7318506&partnerID=40&md5=33c188b777815d735bb181b88a042b5f |
DOI | 10.1109/EMBC.2015.7318506 |
Citation Key | Lopresto2015893 |