In this paper, we attack the problem of the mathematical modelling of mesoscopic morphological changes of the cathode morphology, related to material evolution (typically: lithiation in the first stages of operation of a pristine cell) and degradation (assumed to be controlled by agglomeration of the micrometric NiO particles). The integration domain of the model has been based on microscopic investigations of pristine and used NiO cathodes, the electrochemical results derived from the model have been validated with experimental results, both original and derived from the literature.