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Use of hematopoetic cytokines to accelerate the recovery of the immune system in irradiated mice

TitoloUse of hematopoetic cytokines to accelerate the recovery of the immune system in irradiated mice
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione1997
AutoriFrasca, D., Guidi F., Arbitrio M., Pioli Claudio, Leter Giorgio, Spanò M., and Doria G.
RivistaExperimental Hematology
Volume25
Paginazione1167-1171
ISSN0301472X
Parole chiaveanimal, animal cell, animal experiment, animal model, animal tissue, Animals, article, B lymphocyte, B-Lymphocytes, bone marrow, bone marrow cell, Bone Marrow Cells, C57BL mouse, CD4+ T lymphocyte, CD4-Positive T-Lymphocytes, CD8+ T lymphocyte, CD8-Positive T-Lymphocytes, Cell cycle, cell differentiation, cell growth, concanavalin a, controlled study, cytokine, Cytokines, Dose-Response Relationship, drug effect, Flow cytometry, hematopoiesis, human, Humans, immune response, immunology, Inbred C57BL, interleukin 11, interleukin 3, Interleukin-11, Interleukin-3, lymphocyte, male, Mice, mitosis, mitosis index, Mitotic Index, mouse, nonhuman, priority journal, Radiation, radiation dose, Radiation exposure, radiation injury, radiation response, recombinant interleukin 11, recombinant interleukin 3, recombinant protein, Recombinant Proteins, Spleen, subcutaneous drug administration, T lymphocyte, T-Lymphocytes, thymus, Thymus Gland, whole body radiation, Whole-Body Irradiation, X ray, X-Rays
Abstract

In our previous studies aimed at designing appropriate strategies to accelerate recovery of the immune system after irradiation, we found that the hematopoietic cytokine recombinant murine (rmu) interleukin (IL)-3 was able to induce differentiation and growth of thymocytes and splenic T and B lymphocytes in mice exposed to x-rays (200-500 cGy). The recovery, however, was complete at 7 days only after a dose of 200 cGy, whereas 2, 3, and 4 weeks were necessary to achieve full recovery after 300, 400, and 500 cGy, respectively. These studies were extended to investigate the effects of another hematopoietic cytokine, recombinant human (rhu) IL-11, a bone marrow stromal-derived cytokine, administered together with IL-3 to irradiated mice. The synergistic effect of the two cytokines was evident when relatively small doses of rhu IL-11 were injected with an optimal dose of rmu IL-3.

Note

cited By 6

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0030611033&partnerID=40&md5=d5a1e5fa04370377615aee1868a37f18
Citation KeyFrasca19971167