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Do human lymphocytes exposed to the fallout of the Chernobyl accident exhibit an adaptive response? III. Challenge with bleomycin in lymphocytes from children hit by the initial acute dose of ionizing radiation

TitoloDo human lymphocytes exposed to the fallout of the Chernobyl accident exhibit an adaptive response? III. Challenge with bleomycin in lymphocytes from children hit by the initial acute dose of ionizing radiation
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione1996
AutoriTedeschi, B., Caporossi D., Vernole P., Padovani Laura Maria, and Mauro Francesco
RivistaMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume354
Paginazione77 - 80
Data di pubblicazione1996///
Parole chiaveAdaptive response, Bleomycin, Chernobyl, Chromosome aberration
Abstract

In the present paper, we report data on the possible adaptive response, induced in vivo by exposure to ionizing radiation to a challenge treatment with the radiomimetic glycopeptide bleomycin (BLM). Lymphocytes from children living in Pripjat at the time of the Chernobyl accident, and thus hit by the initial acute dose of ionizing radiation, were treated for the last 5 h of culture with 0.004 U/ml BLM. Significantly lower chromosome damage was found only in lymphocytes from children who, independently of the initial acute exposure to ionizing radiation, still showed a 137Cs internal contamination, due to persistent continuous exposure to low doses of radiation. The present results indicate that past exposure to acute high dose of ionizing radiation does not interfere with resistance to BLM which is related to internal contamination.

Note

Cited By (since 1996): 23Export Date: 26 August 2010Source: Scopus

URLhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0030570506&partnerID=40&md5=0806d012ee929b012e366c0ae221bb84
Citation Key452