Titolo | A Systematic Review on the In Vivo Studies on Radiofrequency (100 kHz–300 GHz) Electromagnetic Field Exposure and Co-Carcinogenesis |
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Tipo di pubblicazione | Articolo su Rivista peer-reviewed |
Anno di Pubblicazione | 2024 |
Autori | Pinto, Rosanna, Ardoino Lucia, Giardullo Paola, Villani Paola, and Marino Carmela |
Rivista | International Journal of Environmental Research and Public Health |
Volume | 21 |
ISSN | 16617827 |
Parole chiave | attributional bias, benign lung tumor, benign neoplasm, benzo[a]pyrene, cancer incidence, cancer survival, carcinogen, clinical outcome, Cocarcinogenesis, Correlation analysis, data extraction, decision making, diethylnitrosamine, dimethylbenz[a]anthracene, dimethylhydrazine, electromagnetic field, electromagnetism, ethylnitrosourea, experimental design, exposure, genotoxicity, GRADE approach, health impact, human, in vivo study, latent period, literature review, malignant neoplasm, meta analysis, Mortality, Oxidative stress, phorbol 13 acetate 12 myristate, practice guideline, Quality control, radiofrequency, randomization, Regression analysis, Reliability, review, Risk assessment, screening, Survival Analysis, systematic review, telecommunication, Tumor, tumor cell, tumor growth, tumor promotion, Ultraviolet radiation |
Abstract | In this systematic review, the potential role of in vivo RF–EMF exposure combined with the administration of well-known carcinogens in tumor promotion/progression is assessed. A total of 25 papers were included in the review. Each paper was assessed for Risk of Bias and for the attribution of the quality category. A meta-analysis was conducted on 18 studies, analyzing data for nine different organs/tumors to assess the potential increased risk for the onset of tumors as well as the effects on survival. A descriptive review was performed for the remaining seven eligible papers. In most cases, the results of the meta-analysis did not reveal a statistically significant difference in tumor onset between the sham and co-exposed samples. There was a numerically small increase in the risk of malignant tumors observed in the kidney and liver, as well as benign lung tumors. The level of evidence for health effects indicated “inadequate” evidence for an association between in vivo co-exposure to RF–EMF and known carcinogens and the onset of malignant or benign tumors in most of the analyzed tissues. Nevertheless, the limited number of eligible papers/studies for most of the analyzed tissues suggests that these results cannot be considered definitively conclusive. © 2024 by the authors. |
Note | cited By 0 |
URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85202603783&doi=10.3390%2fijerph21081020&partnerID=40&md5=2c53663550eee85db601cdbdf3d57897 |
DOI | 10.3390/ijerph21081020 |
Citation Key | Pinto2024 |