Total lipids (TL) (2.1%), more than half of which were glycolipids (GL) (1.3%), and neutral lipids (NL) (0.54%) and phospholipids (PL) (0.26%) were isolated from the air-dried aerial part of Scutellaria ramosissima. The principal acids of the NL were 16:0, 18:2, and 18:3. Acid 16:0 (up to 40 mass% of the acids) dominated the glycolipids. Palmitic and linoleic acids dominated the PL with 18:1 in combination with 18:3 comprising slightly greater than 31%, like linoleic acid. The chlorophyll content was 197.3 mg% in the total lipids; carotinoids, 157.1 mg%; tocopherols, 357.0 mg% in unsaponified substances (US). The cytotoxic activity of the S. ramosissima lipid fractions was tested on HL-60 and HeLa cancer cell lines using the MTT test. PL, NL, and US showed cytotoxicity for HL-60 cells with IC50 values of 8.3, 22.0, and 24.3 μg/mL, respectively, and were inactive for HeLa cells. The GL and TL turned out to be slightly active. © 2014 Springer Science+Business Media New York.

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