The structural diagnosis of historic buildings should integrate on-site and in-the-laboratory experimental testing techniques, with no harmful effects on the structural and aesthetic health of the monument. In the present paper several nondestructive tests (NDTs) were conducted to study an archeological ruined building located in Rome, the so-called Temple of Minerva Medica. In particular, the experimental program comprised 3D geometric surveys by laser scanning and stereo-photogrammetry, thermal imaging, microclimatic parameters acquisition, sonic testing and ambient vibration monitoring. The above NDTs were executed from summer of 2016 until summer of 2017, in order to investigate the seasonal effects and/or the eventual changes in the structural response of the building, after the 2016-2017 Central Italy seismic sequence. The acquired data were stored in a repository that is available to the end-users for future studies and analyses. © (2017) by the International Measurement Confederation (IMEKO). All rights reserved.