| Titolo | Novel passive element circuits for microdosimetry of nanosecond pulsed electric fields |
|---|---|
| Tipo di pubblicazione | Articolo su Rivista peer-reviewed |
| Anno di Pubblicazione | 2012 |
| Autori | Merla, Caterina, Denzi A., Paffi A., Casciola M., Dinzeo G., Apollonio F., and Liberti M. |
| Rivista | IEEE Transactions on Biomedical Engineering |
| Volume | 59 |
| Paginazione | 2302-2311 |
| ISSN | 00189294 |
| Parole chiave | amplitude modulation, article, Bioelectric potentials, Biological, Biological cells, cell membrane, Cell model, Cellular levels, Circuit models, Cytological Techniques, cytoplasm, Dielectric parameters, electric current, Electric fields, Electromagnetic Fields, electroporation, Input pulse, Medical applications, membrane potential, Membrane Potentials, Micro-dosimetry, microdosimetry, Models, Nanosecond pulsed electric fields, nanotechnology, Passive elements, Permittivity, pulsed electric field, radiometry, Sensitivity studies, Time and frequency domains, Transmembrane potentials |
| Abstract | Microdosimetric models for biological cells have assumed increasing significance in the development of nanosecond pulsed electric field technology for medical applications. In this paper, novel passive element circuits, able to take into account the dielectric dispersion of the cell, are provided. The circuital analyses are performed on a set of input pulses classified in accordance with the current literature. Accurate data in terms of transmembrane potential are obtained in both time and frequency domains for different cell models. In addition, a sensitivity study of the transfer function for the cell geometrical and dielectric parameters has been carried out. This analysis offers a new, simple, and efficient tool to characterize the nsPEFs action at the cellular level. © 2012 IEEE. |
| Note | cited By 43 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864245303&doi=10.1109%2fTBME.2012.2203133&partnerID=40&md5=2a1a42012679b2be896626901bdfcfa3 |
| DOI | 10.1109/TBME.2012.2203133 |
| Citation Key | Merla20122302 |
