Title | DNA content differences in laboratory mouse strains determined by flow cytometry |
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Publication Type | Articolo su Rivista peer-reviewed |
Year of Publication | 1997 |
Authors | Capparelli, R., Cottone C., D’Apice L., Viscardi M., Colantonio L., Lucretti Sergio, and Iannelli D. |
Journal | Cytometry |
Volume | 29 |
Pagination | 261 - 266 |
Date Published | 1997/// |
Keywords | Flow cytometry, Laboratory mouse strains, Nuclear DNA content |
Abstract | The nuclear DNA content of seven mouse laboratory strains has been measured by flow cytometry. The differences observed between strains as well as those between sexes within the strain were all statistically significant. The highest DNA content (approximately 6.4 pg/female nucleus) was found in the Balb/c strain; the lowest (approximately 5.7 pg/male nucleus) in the C3H/he strain. The difference between sexes varied from 1.6% (in CD-1 mice) to 6.3% (in nude mice). The interest of these results is twofold. First, the mouse can now be used to study the adaptive significance of genome size variation, so far studied only in plants. Second, DNA content analysis can become a quick method for mouse strain identification. |
Notes | Cited By (since 1996): 12Export Date: 26 August 2010Source: Scopus |
URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-0030810202&partnerID=40&md5=c78069ac76b275e48488a64d69592f8d |
Citation Key | 438 |