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DNA content differences in laboratory mouse strains determined by flow cytometry

TitleDNA content differences in laboratory mouse strains determined by flow cytometry
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication1997
AuthorsCapparelli, R., Cottone C., D’Apice L., Viscardi M., Colantonio L., Lucretti Sergio, and Iannelli D.
JournalCytometry
Volume29
Pagination261 - 266
Date Published1997///
KeywordsFlow cytometry, Laboratory mouse strains, Nuclear DNA content
Abstract

The nuclear DNA content of seven mouse laboratory strains has been measured by flow cytometry. The differences observed between strains as well as those between sexes within the strain were all statistically significant. The highest DNA content (approximately 6.4 pg/female nucleus) was found in the Balb/c strain; the lowest (approximately 5.7 pg/male nucleus) in the C3H/he strain. The difference between sexes varied from 1.6% (in CD-1 mice) to 6.3% (in nude mice). The interest of these results is twofold. First, the mouse can now be used to study the adaptive significance of genome size variation, so far studied only in plants. Second, DNA content analysis can become a quick method for mouse strain identification.

Notes

Cited By (since 1996): 12Export Date: 26 August 2010Source: Scopus

URLhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0030810202&partnerID=40&md5=c78069ac76b275e48488a64d69592f8d
Citation Key438