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A Microdosimetric Realistic Model to Study Frequency-Dependent Electroporation in a Cell with Endoplasmic Reticulum

TitleA Microdosimetric Realistic Model to Study Frequency-Dependent Electroporation in a Cell with Endoplasmic Reticulum
Publication TypePresentazione a Congresso
Year of Publication2019
AuthorsDe Angelis, A., Denzi A., Merla Caterina, Andre F.M., Garcia-Sanchez T., Mir L.M., Apollonio F., and Liberti M.
Conference Name2019 49th European Microwave Conference, EuMC 2019
KeywordsAC signals, Electric fields, electroporation, endoplasmic reticulum, Endoplasmic reticulum membranes, Frequency dependent, Higher efficiency, Microwave electric field, Microwaves, Numerical models, Radiofrequency signals, Subcellular structure
Abstract

The study of the frequency-dependent response of a biological cell and its organelles to an intense electric field is of growing interest in the bioelectromagnetic area. The possibility offered by continuous waves to uncouple the effects of the electric field during electroporation is employed in this work using a numerical model including the realistic shape of cell and endoplasmic reticulum membranes. The higher efficiency of the microwave signals in electroporating the subcellular structures, in comparison with the radiofrequency signals, is highlighted. © 2019 European Microwave Association (EuMA).

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85076351370&doi=10.23919%2fEuMC.2019.8910909&partnerID=40&md5=c9249661f5ee62cd2c2a876f37074e7f
DOI10.23919/EuMC.2019.8910909
Citation KeyDeAngelis2019212