| Title | Characterization of a 50-Ω exposure setup for high-voltage nanosecond pulsed electric field bioexperiments |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2011 |
| Authors | Kenaan, M., Amari S.E., Silve A., Merla Caterina, Mir L.M., Couderc V., Arnaud-Cormos D., and Leveque P. |
| Journal | IEEE Transactions on Biomedical Engineering |
| Volume | 58 |
| Pagination | 207-214 |
| ISSN | 00189294 |
| Keywords | Analytical model, article, Bandwidth, Biological cuvette matching bandwidth, biomechanics, Computer simulation, Electric fields, Electric Impedance, Electric potential, Electricity, electrode, Electrodes, Electromagnetic Fields, electroporation, Experimental data, Experimental measurements, exposure, Exposure system, Finite difference time domain method, Finite difference time domains, finite-difference time domain (FDTD), Frequency characterization, High intensity, high voltage (HV), High voltage generators, High-voltage measurement, High-voltages, mathematical model, Mathematical models, measurement, nanoengineering, Nanosecond pulsed electric fields, Numerical calculation, Optical instruments, process model, pulse generator, pulsed electric field, Short durations, Time domain, Voltage distribution |
| Abstract | An exposure system for a nanosecond pulsed electric field is presented and completely characterized in this paper. It is composed of a high-voltage generator and an applicator: the biological cuvette. The applied pulses have high intensities (up to 5 kV), short durations (3 and 10 ns), and different shapes (square, bipolar). A frequency characterization of the cuvette is carried out based on both an analytical model and experimental measurements (S11) in order to determine its matching bandwidth. High voltage measurements in the time domain are performed. Results show that the cuvette is well adapted to 10-ns pulses and limited to those of 3 ns. The rise/fall times of the pulses should not be less than 1.5 ns. In addition, numerical calculation providing voltage distribution within the cuvette is performed using an in-house finite-difference time-domain code. A good level of voltage homogeneity across the cuvette electrodes is obtained, as well as consistency with experimental data for all the applied pulses. © 2011 IEEE. |
| Notes | cited By 42 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79551528836&doi=10.1109%2fTBME.2010.2081670&partnerID=40&md5=8c21ae4ed877019e50e02ad650fb96cc |
| DOI | 10.1109/TBME.2010.2081670 |
| Citation Key | Kenaan2011207 |
