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Microdosimetry applied to nanosecond pulsed electric fields: a comparison on a single cell between real and ideal waveforms.

TitleMicrodosimetry applied to nanosecond pulsed electric fields: a comparison on a single cell between real and ideal waveforms.
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2011
AuthorsMerla, Caterina, Paffi A., Apollonio F., Leveque P., and Liberti M.
JournalConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
Volume2011
Pagination302-305
ISSN1557170X
Keywordsanimal, Animals, article, Biological, biological model, cell membrane, Computer simulation, human, Humans, methodology, Models, physiology, Radiation Dosage, radiation dose, Radiation exposure, radiometry
Abstract

A microdosimetric analysis using ideal and real pulses was carried out in this paper. To perform this goal, authors employed an algorithm developed recently for nsPEF based on Laplace's equation and able to take into account cell compartment dispersivity. A comparison between biphasic real and ideal waveforms was carried out. The ideal pulse induced the highest pore density efficiency, hence evidencing that a device optimization to avoid waveform degradation and losses has a fundamental impact on the performances of the delivered pulses at the single cell level.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84891683705&partnerID=40&md5=ff2ee4d16970dbe0cb6c496d72fbedad
Citation KeyMerla2011302