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Microdosimetry applied to nanosecond pulsed electric fields: A comparison on a single cell between real and ideal waveforms

TitleMicrodosimetry applied to nanosecond pulsed electric fields: A comparison on a single cell between real and ideal waveforms
Publication TypePresentazione a Congresso
Year of Publication2011
AuthorsMerla, Caterina, Paffi A., Apollonio F., Leveque P., and Liberti M.
Conference NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
KeywordsBiphasic, Cells, Device optimization, dispersivity, Electric fields, Laplace equation, Laplace transforms, Laplace's equations, Micro-dosimetry, Nanosecond pulsed electric fields, Pore densities, Single cells, Single-cell level, Wave forms, Waveform degradation
Abstract

A microdosimetric analysis using ideal and real pulses was carried out in this paper. To perform this goal, authors employed an algorithm developed recently for nsPEF based on Laplace's equation and able to take into account cell compartment dispersivity. A comparison between biphasic real and ideal waveforms was carried out. The ideal pulse induced the highest pore density efficiency, hence evidencing that a device optimization to avoid waveform degradation and losses has a fundamental impact on the performances of the delivered pulses at the single cell level. © 2011 IEEE.

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84055212372&doi=10.1109%2fIEMBS.2011.6090079&partnerID=40&md5=a8572219e0b93dec6b08e2baccd5f2ac
DOI10.1109/IEMBS.2011.6090079
Citation KeyMerla2011302