| Title | Controllable release from high-transition temperature magnetoliposomes by low-level magnetic stimulation |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2015 |
| Authors | Spera, R., Apollonio F., Liberti M., Paffi A., Merla Caterina, Pinto Rosanna, and Petralito S. |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Volume | 131 |
| Pagination | 136-140 |
| ISSN | 09277765 |
| Keywords | algorithm, Algorithms, Alternating magnetic field, article, bilayer membrane, Calorimetry, Chemical, chemical model, chemistry, Controllable release, controlled drug release, controlled study, Differential Scanning, Differential scanning calorimetry, Drug delivery, Electric conductivity, electromagnetic field, Electromagnetic Fields, Heat, High reproducibility, High temperature, Hot Temperature, Hydration, lipid, Lipids, liposome, liposome membrane, Liposomes, magnetic field, Magnetic fields, Magnetic stimulation, Magnetics, Magnetism, magnetite nanoparticle, Magnetite Nanoparticles, magnetoliposome, Magnetoliposomes, mathematical model, mechanical stress, Models, Multiphysics simulations, Nanoparticles, oscillation, phase transition, priority journal, reproducibility, simulation, spectrophotometry, Static Electricity, Stimuli-responsive, Stresses, Temperature increase, Temperature sensitivity, transition temperature, unclassified drug |
| Abstract | High-transition temperature liposomes with embedded coated magnetite nanoparticles were prepared using the thin lipid film hydration method in order to obtain magnetoliposomes not sensitive to temperature increase (at least up to 50. °C). Accordingly, drug can be released from such magnetoliposomes using a low-level electromagnetic field as triggering agent, while no delivery would be obtained with temperature increase within the physiological acceptable range. The hypothesized release mechanism involves mechanical stress of the liposome membrane due to nanoparticles oscillations and it is investigated by means of a numerical model evaluated using multiphysics simulations. The carrier content was repetitively released by switching on and off a 20. kHz, 60. A/m magnetic field. The results indicated high reproducibility of cycle-to-cycle release induced by the magnetic-impelled motions driving to the destabilization of the bilayer rather than the liposome phase transition or the destruction of the liposome structure. © 2015 Published by Elsevier B.V. |
| Notes | cited By 12 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930666570&doi=10.1016%2fj.colsurfb.2015.04.030&partnerID=40&md5=4f86d12b9522f29789044526412c8f7a |
| DOI | 10.1016/j.colsurfb.2015.04.030 |
| Citation Key | Spera2015136 |
