In the last decades, the advances in the micro and nano-fabrication techniques have led to the development of microdevices that have improved the possibility of analysis at cell level. These devices can be used in different applications: cell detection and identification, manipulation, cell treatments, but in particular they seem extremely promising for nanosecond pulses applications, where the requisite of broadband matching becomes highly demanding. In this paper after a brief review of applicators for nanosecond pulses, a multi step procedure for a good design of microdevices is fixed and an example of microchamber design is given. © 2017 Euraap.