| Title | Effect of nanoparticles and environmental particles on a cocultures model of the air-blood barrier |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2013 |
| Authors | Bengalli, R., Mantecca P., Camatini M., and Gualtieri Maurizio |
| Journal | BioMed Research International |
| Volume | 2013 |
| ISSN | 23146133 |
| Keywords | air blood barrier, article, Blood-Air Barrier, cell adhesion, Cell Line, chemistry, coculture, Coculture Techniques, copper oxide, cytokine release, cytology, drug effect, Electric Impedance, electron, Endothelial Cells, endothelium cell, Epithelial Cells, epithelium cell, human, human cell, human cell culture, Humans, immunohistochemistry, impedance, in vitro study, inflammation, interleukin 1beta, interleukin 6, interleukin 8, lung alveolus, lung alveolus epithelium, lung endothelium, lung gas exchange, microcirculation, Microscopy, molecular interaction, nanoparticle, Nanoparticles, oxide, Oxides, particulate matter, permeability barrier, Pulmonary Alveoli, respiratory system, Titanium dioxide, Transmission, Transmission electron microscopy |
| Abstract | Exposure to engineered nanoparticles (NPs) and to ambient particles (PM) has increased significantly. During the last decades the application of nano-objects to daily-life goods and the emissions produced in highly urbanized cities have considerably augmented. As a consequence, the understanding of the possible effects of NPs and PM on human respiratory system and particularly on the air-blood barrier (ABB) has become of primary interest. The crosstalk between lung epithelial cells and underlying endothelial cells is indeed essential in determining the effects of inhaled particles. Here we report the effects of metal oxides NPs (CuO and TiO and of PM on an in vitro model of the ABB constituted by the type II epithelial cell line (NCI-H441) and the endothelial one (HPMEC-ST1.6R). The results demonstrate that apical exposure of alveolar cells induces significant modulation of proinflammatory proteins also in endothelial cells. © 2013 Rossella Bengalli et al. |
| Notes | cited By 5 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874602363&doi=10.1155%2f2013%2f801214&partnerID=40&md5=d58a7133bca3149cdf1d6c1c318f7896 |
| DOI | 10.1155/2013/801214 |
| Citation Key | Bengalli2013 |
