| Title | Particle size, chemical composition, seasons of the year and urban, rural or remote site origins as determinants of biological effects of particulate matter on pulmonary cells |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2013 |
| Authors | Perrone, M.G., Gualtieri Maurizio, Consonni V., Ferrero L., Sangiorgi G., Longhin E., Ballabio D., Bolzacchini E., and Camatini M. |
| Journal | Environmental Pollution |
| Volume | 176 |
| Pagination | 215-227 |
| ISSN | 02697491 |
| Keywords | A549 cells, aerosol, aerosol composition, Air Pollutants, Air pollution, alkane, Aluminum, Ammonia, arsenic, article, atmospheric transport, Biological effects, Biological response, calcium ion, carbon, carboxylic acid, cell assay, Cell Line, cell stress, cell viability, Chemical composition, Chemical compositions, Chemical compounds, Chemical constituents, chemometrics, Chromium, concentration (composition), concentration (parameters), controlled study, cytokine release, Cytotoxicity, Discriminant analysis, DNA damage, Elemental carbon, Environmental impact, Environmental monitoring, genotoxicity, Health effects, health impact, High concentration, human, human cell, Humans, in vitro study, In-vitro, interleukin 8, Iron, Italy, lactate dehydrogenase, Land use, Lead, least squares method, levoglucosan, long range transport, lung alveolus cell, lung toxicity, magnesium ion, Metals, Molybdenum, nitrate, Oxidative stress, Partial least square (PLS), particle size, particulate matter, point source, polycyclic aromatic hydrocarbon, Pulmonary Alveoli, reactive oxygen metabolite, remote site, Remote sites, rural area, seasonal variation, Seasons, Secondary sources, sulfate, Toxic effect, Trace metal, troposphere, Tropospheric aerosols, unclassified drug, urban area, Urban growth, urban rural difference, Zinc |
| Abstract | Particulate matter (PM), a complex mix of chemical compounds, results to be associated with various health effects. However there is still lack of information on the impact of its different components. PM2.5 and PM1 samples, collected during the different seasons at an urban, rural and remote site, were chemically characterized and the biological effects induced on A549 cells were assessed. A Partial Least Square Discriminant Analysis has been performed to relate PM chemical composition to the toxic effects observed. Results show that PM-induced biological effects changed with the seasons and sites, and such variations may be explained by chemical constituents of PM, derived both from primary and secondary sources. The first-time here reported biological responses induced by PM from a remote site at high altitude were associated with the high concentrations of metals and secondary species typical of the free tropospheric aerosol, influenced by long range transports and aging. © 2013 Elsevier Ltd. All rights reserved. |
| Notes | cited By 47 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874669249&doi=10.1016%2fj.envpol.2013.01.012&partnerID=40&md5=0ffbe2e7b36e70d136cb9b101c164c33 |
| DOI | 10.1016/j.envpol.2013.01.012 |
| Citation Key | Perrone2013215 |
