| Title | Synergistic inflammatory effect of PM10 with mycotoxin deoxynivalenol on human lung epithelial cells |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2015 |
| Authors | Capasso, L., Longhin E., Caloni F., Camatini M., and Gualtieri Maurizio |
| Journal | Toxicon |
| Volume | 104 |
| Pagination | 65-72 |
| ISSN | 00410101 |
| Keywords | air pollutant, Air Pollutants, article, Cell cycle, cell cycle arrest, cell death, Cell Line, Cell Survival, concentration (parameters), controlled study, cytokine release, cytology, Cytotoxicity, dose response, Dose-Response Relationship, Drug, drug effects, drug potentiation, Drug Synergism, Epithelial Cells, epithelium cell, Fusarium, human, human cell, Humans, IL6 protein, IL8 protein, inflammation, interleukin 6, interleukin 8, Interleukin-6, Interleukin-8, lung, lung alveolus epithelium cell, metabolism, mitogen activated protein kinase, particulate matter, priority journal, season, seasonal variation, Seasons, summer, Toxicity, trichothecene derivative, Trichothecenes, Tumor, tumor cell line, vomitoxin, winter |
| Abstract | Abstract The presence of deoxynivalenol (DON), a mycotoxin produced by Fusarium species, has been reported worldwide in food and feedstuffs. Even though oral intake is the main route of exposure, DON inhalation is also of concern in workers and exposed population. Particulate matter (PM) is one of the most important causes of air quality detriment and it induces several adverse health effects. Therefore it is of primary importance to understand possible combined effects of DON and PM. The alveolar type II, A549, and the bronchial epithelial, BEAS-2B, cell lines were exposed for 24 h to different concentrations of DON (10-1000 ng/ml), PM10 (5 μg/cm2, sampled in summer or winter season), and a combination of these pollutants. Cell death, interleukins release and cell cycle alteration were analysed; protein array technique was also applied to evaluate proteins activation related to MAP-kinases cascade. Our results demonstrate that low doses of PM and DON used alone have scarce toxic effects, while induce cytotoxicity and inflammation when used in combination. This observation outlines the importance of investigation on the combined effects of air pollutants for their possible outcomes on human health. © 2015 Elsevier Ltd. |
| Notes | cited By 2 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84939515860&doi=10.1016%2fj.toxicon.2015.08.008&partnerID=40&md5=b5cccbb8b594ff708c7a2efec5aa5fec |
| DOI | 10.1016/j.toxicon.2015.08.008 |
| Citation Key | Capasso201565 |
