| Title | Observation of non-covalent interactions between beauvericin and oligonucleotides using electrospray ionization mass spectrometry |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 1997 |
| Authors | Pocsfalvi, G., Di Landa G., Ferranti P., Ritieni A., Randazzo G., and Malorni A. |
| Journal | Rapid Communications in Mass Spectrometry |
| Volume | 11 |
| Pagination | 265-272 |
| ISSN | 09514198 |
| Keywords | Anti-Bacterial Agents, antiinfective agent, article, beauvericin, chemistry, depsipeptide, Depsipeptides, DNA, DNA fragment, DNA fragmentation, drug effect, Fermentation, Fungal, fungal DNA, Fusarium, isolation and purification, Mass Spectrometry, metabolism, oligonucleotide, Oligonucleotides, peptide, Peptides |
| Abstract | Electrospray ionization mass spectrometry has been used to study the possible non-covalent interaction between oligonucleotides and beauvericin (B) mycotoxin. Beauvericin-oligonucleotide adduct formation was observed even at low mycotoxin concentration (25pmol/μL). Adducts were found with different numbers of B ligands attached. The selectivity of binding of B ligands to two different oligonucleotides has been shown to be similar indicating that beauvericin does not have a strongly preferred base sequence or base site in the DNA. In a competitive complexation reaction, beauvericin forms specific adducts with oligonucleotide while another mycotoxin, nigeromicin, which causes apoptosis without fragmentation of DNA, does not. |
| Notes | cited By 30 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030940152&doi=10.1002%2f%28SICI%291097-0231%2819970215%2911%3a3%3c265%3a%3aAID-RCM848%3e3.0.CO%3b2-2&partnerID=40&md5=7cb1ba04afe66220fb864e914671259f |
| DOI | 10.1002/(SICI)1097-0231(19970215)11:3<265::AID-RCM848>3.0.CO;2-2 |
| Citation Key | Pócsfalvi1997265 |
