| Title | Single-nucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2010 |
| Authors | Sterpone, S., Mastellone V., Padua L., Novelli Flavia, Patrono Clarice, Cornetta T., Giammarino D., Donato V., Testa Antonella, and Cozzi R. |
| Journal | Journal of Cancer Research and Clinical Oncology |
| Volume | 136 |
| Pagination | 631-636 |
| ISSN | 01715216 |
| Keywords | 8 oxoguanine dna glycosylase, adult, aged, article, Breast cancer, Breast Neoplasms, cancer radiotherapy, cancer risk, Caucasian, clinical article, codon, controlled study, DNA Glycosylases, DNA glycosyltransferase, DNA-Binding Proteins, European Continental Ancestry Group, excision repair, Female, gene frequency, Genetic Predisposition to Disease, haplotype, Haplotypes, homologous recombination, human, Humans, Middle Aged, Polymerase Chain Reaction, Polymorphism, priority journal, restriction fragment length polymorphism, Risk Factors, Single Nucleotide, single nucleotide polymorphism, unclassified drug, XRCC1 protein, XRCC3 protein |
| Abstract | {Purpose: This study aimed to assess whether haplotypes in XRCC1 and SNPs in OGG1 and XRCC3 were associated with an increased risk of developing breast cancer (BC) and early adverse reactions after radiotherapy. Methods: 43 Italian breast cancer patients and 31 healthy controls were genotyped for XRCC1(-77T→C,194,399), OGG1-326 and XRCC3-241 by RFLP-PCR. Results: XRCC1-77T→C, XRCC1-194, OGG1 and XRCC3 were not associated with BC. On the contrary, we found a significant association (p ≤ 0.05) between breast cancer occurrence and XRCC1-399. The haplotype (H3) containing the variant allele at codon 399, together with variant C allele in the promoter and wild-type G allele at codon 194 was associated with higher BC risk [p = 0.009 |
| Notes | cited By 35 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77949268356&doi=10.1007%2fs00432-010-0791-1&partnerID=40&md5=a211a39e188884efa63e10fe6b50b456 |
| DOI | 10.1007/s00432-010-0791-1 |
| Citation Key | Sterpone2010631 |
