| Title | Hematopoietic reconstitution after lethal irradiation and bone marrow transplantation: Effects of different hematopoietic cytokines on the recovery of thymus, spleen and blood cells |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2000 |
| Authors | Frasca, D., Guidi F., Arbitrio M., Pioli Claudio, Poccia F., Cicconi R., and Doria G. |
| Journal | Bone Marrow Transplantation |
| Volume | 25 |
| Pagination | 427-433 |
| ISSN | 02683369 |
| Keywords | animal cell, animal experiment, Animals, article, blood cell, Blood Cells, bone marrow transplantation, controlled study, cytokine, Female, Graft Survival, hematopoiesis, Inbred C57BL, interleukin 11, interleukin 3, interleukin 6, Interleukin-11, Interleukin-3, Interleukin-6, irradiation, Isogeneic, lymphoid tissue, male, Mice, mouse, nonhuman, priority journal, Spleen, spleen cell, stem cell factor, thymocyte, Thymus Gland, transplantation, Whole-Body Irradiation |
| Abstract | Lethally irradiated mice were grafted with syngeneic bone marrow cells or left ungrafted. Mice of each group were injected with different hematopoietic cytokines for 5 consecutive days starting immediately after irradiation or left uninjected. The recovery of lymphoid tissues induced by hematopoietic cytokines 7 days after irradiation and bone marrow cell transplantation was comparable to that observed at days 21-28 in irradiated, bone marrow-grafted, but cytokine-uninjected mice. IL-11 or IL-6, in combination with IL-3, was able to hasten thymus, spleen and blood cell numbers and functions. SCF also displayed a detectable effect when used with IL-3. Conversely, the IL-6 superagonist K-7/D-6 was able, when injected alone, to induce significant recovery of thymus, spleen and blood cells. Thus, K-7/D-6 appears to be a most efficient cytokine for fast reconstitution of lymphoid tissues after irradiation and bone marrow transplantation. |
| Notes | cited By 15 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034005124&partnerID=40&md5=5f940416042fc43350747cba24f82ae7 |
| Citation Key | Frasca2000427 |
