| Title | Site-specific conjugation of ScFvs antibodies to nanoparticles by bioorthogonal strain-promoted alkyne-nitrone cycloaddition |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2012 |
| Authors | Colombo, M., Sommaruga S., Mazzucchelli S., Polito L., Verderio P., Galeffi Patrizia, Corsi F., Tortora P., and Prosperi D. |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Pagination | 496 - 499 |
| Date Published | 2012/// |
| Keywords | bioorthogonal reaction, cell targeting, cycloaddition, Nanoparticles, scFv antibody |
| Abstract | Particularly suitable: An N-terminal serine mutant of anti-HER2 scFv antibody was conjugated to polymer-coated magnetofluorescent nanoparticles by strain-promoted alkyne-nitrone cycloaddition. The resulting nanoparticles (see scheme) proved effective in targeting and labeling HER2-positive breast cancer cells. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| Notes | Export Date: 22 February 2012Source: Scopus |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-84855426017&partnerID=40&md5=16a9ec6b6a35d29e0be9f59bff2e9dff |
| Citation Key | 3045 |
