| Title | Aloe arborescens extract protects IMR-32 Cells against Alzheimer amyloid beta peptide via inhibition of radical peroxide production |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2015 |
| Authors | Clementi, M.E., Tringali G., Triggiani Doriana, and Giardina B. |
| Journal | Natural Product Communications |
| Volume | 10 |
| Pagination | 1993-1995 |
| ISSN | 1934578X |
| Keywords | Aloe, Aloe arborescens, Aloe arborescens extract, Alzheimer disease, amyloid beta protein, amyloid beta protein[1-42], Amyloid beta-Peptides, article, Cell Line, Cell Survival, cell viability, chemistry, controlled study, drug effects, Enzyme inhibition, enzyme synthesis, human, human cell, Humans, metabolism, mitochondrion, neuroprotection, oxidation reduction potential, Oxygen consumption, pathophysiology, peroxide, Peroxides, Plant extract, Plant extracts, protective agent, Protective Agents, reactive oxygen metabolite, unclassified drug |
| Abstract | Aloe arborescens is commonly used as a pharmaceutical ingredient for its effect in burn treatment and ability to increase skin wound healing properties. Besides, it is well known to have beneficial phytotherapeutic, anticancer, and radio-protective properties. In this study, we first provided evidence that A. arborescens extract protects IMR32, a neuroblastoma human cellular line, from toxicity induced by beta amyloid, the peptide responsible for Alzheimer's disease. In particular, pretreatment with A. arborescens maintains an elevated cell viability and exerts a protective effect on mitochondrial functionality, as evidenced by oxygen consumption experiments. The protective mechanism exerted by A. arborescens seems be related to lowering of oxidative potential of the cells, as demonstrated by the ROS measurement compared with the results obtained in the presence of amyloid beta (1-42) peptide alone. Based on these preliminary observations we suggest that use of A. arborescens extract could be developed as agents for the management of AD. |
| Notes | cited By 17 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955085487&doi=10.1177%2f1934578x1501001147&partnerID=40&md5=728b6e7f4d6c1b54333b99b660d4bf0a |
| DOI | 10.1177/1934578x1501001147 |
| Citation Key | Clementi20151993 |
